Rapid Development of T Cell Memory

Rapid development of T cell memory.

Prime-boost immunization is a promising strategy for inducing and amplifying pathogen- or tumor-specific memory CD8 T cell responses. Although expansion of CD8 T cell populations following the second Ag dose is integral to the prime-boost strategy, it remains unclear when, after priming, memory T cells become competent to proliferate. In this study, we show that Ag-specific CD8 T cells with the...

Rapid Development of Th2 Activity During T Cell Priming

The paradigm of T helper-1 (Th-1) and Th-2 cells developing from non-committed naive precursors is firmly established. Th1 cells are characterized by IFNgamma production and, in mice, the selective switching to IgG2a. Conversely IL-4 production and selective switching to IgG1 and IgE characterize Th2 cells. Analysis of Th2 induction in vitro indicates that this polarization develops gradually i...

Memory in Rhesus Macaque Development and Homeostasis of T Cell

Development of a Stable Cell Line, Overexpressing Human T-cell Immunoglobulin Mucin 1

Background: Recent researches have demonstrated that human T-cell immunoglobulin mucin 1 (TIM-1) glycoprotein plays important roles in regulation of autoimmune and allergic diseases, as well as in tumor immunity and response to viral infections. Therefore,targeting TIM-1 could be a potential therapeutic approach against such diseases. Objectives: In this study, we aimed to express TIM-1 protein...

E2A Deficiency Leads to Abnormalities in ab T-Cell Development and to Rapid Development of T-Cell Lymphomas

GRETCHEN BAIN, ISAAC ENGEL, ELS C. ROBANUS MAANDAG, HEIN P. J. TE RIELE, JOSEPH R. VOLAND, LESLIE L. SHARP, JEROLD CHUN, BING HUEY, DAN PINKEL, AND CORNELIS MURRE* Department of Biology and Department of Pharmacology, University of California, San Diego, La Jolla, California 92093; Department of Molecular Genetics, The Netherlands Cancer Institute, 1060 CX Amsterdam, The Netherlands; and Cancer...